Decode your DNA. Personalise your healing.

 
 What is it?

 

The SmartDNA Advanced Pathway Test is a comprehensive functional genomics assessment that analyses over 300 gene variants (SNPs) involved in your body’s core pathways - from methylation and detoxification to hormones, neurotransmitters, and inflammation.

 

This test gives us a deeper understanding of your genetic blueprint, empowering us to create a personalised strategy to support your health, vitality, and long-term wellness.

 
 Why Get This Test?

Have you ever felt like something deeper is going on with your health, but standard tests come back “normal”?

Genetic testing offers a new layer of insight - helping uncover the root causes behind challenges like:

  •  Weight loss resistance

  • Poor detoxification or sensitivity to toxins

  • Mood, anxiety, or fatigue that doesn’t shift

  • Methylation issues (e.g., MTHFR gene variants)

  • Brain health and neurotransmitters

  • Dietary recommendations specific to you

  • The personalised need for different nutrients

This is not about diagnosing, but about understanding how your body is wired - and how we can best support it through nutrition, lifestyle, and targeted supplementation.

 

 

The test covers the following:

 

WEIGHT MANAGEMENT & GENETIC INSIGHTS

Why One-Size-Fits-All Weight Loss Doesn’t Work

 

If you’ve ever struggled with weight loss despite doing “all the right things,” your genes may hold the answer. Weight regulation is influenced by far more than just calories in and calories out — it’s impacted by appetite signalling, metabolism, fat storage, food preferences, and how your body responds to different types of exercise and nutrients.

 

The smartDNA Advanced Pathways Test provides deep insight into the genetic factors that influence your ability to lose weight, keep it off, and make sustainable, personalised choices.

 

What We Test

This section of the report explores genetic variants that affect how your body responds to:

 

Dietary fats:

 

APOA2 - increased weight gain risk with saturated fat intake

APOA5 & PPARG - response to monounsaturated fats and fat metabolism

 

 

Cholesterol & hunger hormones:

NPY - predisposition to higher total cholesterol

ADIPOQ - low adiponectin levels associated with weight regain

 

 

Appetite, cravings & snacking:

FTO - reduced satiety, higher food intake, higher BMI

MC4R - increased snacking and appetite dysregulation

DRD2 - linked to food addiction and reward-based eating

SLC2A2 - increased sweet food consumption

TAS2R38 - bitter taste receptor that may affect salt preference

 

Fat burning & metabolism:

ADRB2 & ADRB3 – resistance to fat loss and fat cell breakdown

LEPR – altered leptin signalling and metabolic rate

 

Exercise & macronutrient response:

FTO – response to protein intake and physical activity for weight loss

PPARD – influence on HDL improvement with exercise

 

 Why It Matters

Understanding your genetic blueprint can help you:

 

  • Tailor your diet plan (e.g. higher protein, lower saturated fat, etc.)

  • Choose the most effective type of exercise for fat loss

  •  Understand your triggers for emotional eating, cravings, or food addiction

  •  Avoid frustration and weight regain with more sustainable strategies

  •  Get a clear roadmap for long-term weight maintenance

 

LIPID METABOLISM

Personalised Insight into Your Cholesterol, Fats & Cardiovascular Wellness

 

Your ability to process and respond to dietary fats is influenced not only by lifestyle - but also by your genes. The Lipid Metabolism panel included in the smartDNA Advanced Pathways Test provides essential insight into how your body handles cholesterol, triglycerides and other types of fat.

 

This panel is especially valuable for individuals who:

  • Have elevated cholesterol or triglyceride levels

  • Don’t respond to traditional diet, exercise, or lifestyle changes

  • Have a family history of heart disease or lipid disorders

  • Want a more targeted, preventative approach to cardiovascular wellness

 What We Test

This panel analyses key genes involved in:

  • Fat absorption and transport

  • HDL (“good” cholesterol) and LDL (“bad” cholesterol) balance

  • Triglyceride metabolism

  • Cholesterol clearance and recycling

  • Some of the genes examined include: APOE, APOA1, APOB, APOCIII, APOA5, LDL-R, LPL, ABCA1, CETP, LIPC, eNOS3, FABP2, LPA and more.

 Why It Matters

Variants in these genes can influence:

  • Your response to different types of fat (e.g. saturated vs polyunsaturated fats)

  • How easily your body clears LDL cholesterol

  • The impact of lifestyle habits like alcohol, smoking, or a high-carb diet on lipid levels

  • The effectiveness of dietary and supplement interventions

 

METABOLIC SYNDROME & DIABETES

Genetic Insights Into Blood Sugar, Insulin & Long-Term Metabolic Health

 

Type 2 Diabetes and Metabolic Syndrome (MetS) are among the fastest-growing health challenges globally. While lifestyle and nutrition are major factors, your genetic makeup also plays a critical role in your risk - and how your body responds to sugar, insulin, and fat metabolism.

 

The smart DNA Advanced Pathways Test provides a genetic risk assessment to help identify whether you're predisposed to normal, moderate, or high risk of developing insulin resistance, Metabolic Syndrome, or Type 2 Diabetes.

 

What We Test

Key genes assessed in this panel include:

ACSL1 & ACC2 – involved in fatty acid synthesis and oxidation, which impact insulin sensitivity and fat storage.

TCF7L2, WFS1, SLC30A8 – related to insulin production, secretion, and function.

FTO, G6PC2, PPARG – associated with body weight regulation, blood glucose control, and beta-cell performance.

 

Why It Matters

Genetic variants in these pathways can increase your risk of:

  • Elevated blood sugar and insulin resistance

  • Weight gain and increased BMI

  • Impaired glucose metabolism

  • Poor response to certain dietary fats or carbohydrates

  • Reduced pancreatic beta-cell function (insulin secretion)

 

INFLAMMATION

Your Genetic Blueprint for Inflammation Response

 

Chronic inflammation is at the core of many modern health issues - including diabetes, cardiovascular disease, obesity, osteoporosis, and even accelerated aging.

 

While lifestyle, diet, and stress are major contributors, your genetic susceptibility to inflammation also plays a significant role in how your body reacts and recovers.

 

What We Test

The smartDNA Advanced Pathways Test analyses key gene variants associated with your inflammatory response, including:

TNFA (Tumor Necrosis Factor Alpha) – a key regulator of systemic inflammation

IL6 (Interleukin-6) – a cytokine involved in immune signaling and inflammation

CRP (C-Reactive Protein) – a major marker of chronic low-grade inflammation

 

SODIUM SENSTIVITY

How Your Genes Influence Salt Sensitivity & Cardiovascular Risk

 

High blood pressure (hypertension) is one of the leading causes of stroke and a major risk factor for heart attacks and cardiovascular disease. While diet and lifestyle play important roles, your genetic response to sodium (salt) may also be a hidden driver of elevated blood pressure.

 

The smartDNA Advanced Pathways Test helps uncover whether you carry genetic variants that make you more sensitive to dietary salt.

 

What We Test

This panel focuses on two key genes involved in blood pressure regulation:

ACE (Angiotensin-Converting Enzyme) – regulates blood vessel constriction and fluid balance

AGT (Angiotensinogen) – involved in sodium retention and blood pressure control

 

Why It Matters

People with certain variants in these genes may have:

  • Increased sodium sensitivity

  • Higher plasma angiotensinogen levels

  • Greater risk of developing hypertension, even with moderate salt intake

  • Reduced response to standard dietary interventions

This information is particularly relevant for individuals with family history of high blood pressure, salt retention, or cardiovascular disease, as well as those who don’t respond well to general low-sodium recommendations.

 

COENZYME Q10

Supporting Energy, Heart Health & Antioxidant Protection

 

Coenzyme Q10 (CoQ10) is a vital nutrient involved in energy production within the mitochondria of your cells. It also acts as a powerful antioxidant, protecting your body from oxidative stress and supporting heart, brain, and muscle health.

 

Your ability to produce and recycle CoQ10 can be affected by genetics — and understanding this can help guide personalised support for fatigue, aging, cardiovascular wellness, and overall vitality.

 

What We Test

This panel includes analysis of the NQO1 gene, which plays a role in CoQ10 recycling and antioxidant defense.

NQO1 (NAD(P)H Quinone Dehydrogenase 1) – responsible for converting oxidized CoQ10 back to its active, usable form.

 

Why It Matters

 A variant in the NQO1 gene can lead to:

  •  Reduced enzymatic activity

  •  Impaired one-electron reduction of quinones

  •  Increased production of reactive oxygen species (free radicals)

  •  Less efficient CoQ10 recycling and antioxidant protection. This may result in greater oxidative stress, fatigue, or reduced resilience, especially in individuals exposed to high environmental or metabolic stress.

 

OMEGA 3 & OMEGA 6 BALANCE

Genetic Insights Into Your Body’s Ability to Process Essential Fats

Omega-3 and Omega-6 fatty acids are essential for brain health, hormone production, inflammation regulation, and cardiovascular function. Your body must convert these fats from dietary sources into their active, long-chain forms — and your genes play a key role in how efficiently this happens.

 

What We Test

The smartDNA Advanced Pathways Test examines key genes involved in fatty acid conversion, particularly:

FADS1 (Fatty Acid Desaturase 1) – critical for converting short-chain omega-3 and omega-6 fatty acids into their active long-chain forms.

 

Why It Matters

A variant in the FADS1 gene is associated with:

  • Reduced blood levels of EPA and AA

  • Impaired conversion of plant-based omega-3s (ALA) into active EPA and DHA

  • A possible imbalance in omega-3 to omega-6 ratio

  • Increased need for direct sources of long-chain omega-3s (like fish oil)

This may affect inflammation regulation, cognitive function, skin health, and cardiovascular resilience — especially in those with a diet low in fish or high in processed omega-6 fats.

 

VITAMINS

Assessing the genes that may cause lower levels of certain vitamins

Even with a healthy diet, genetic variations can influence how effectively your body absorbs, transports, activates, and utilises essential vitamins. These micronutrients are critical for energy production, immune function, detoxification, mood, and hormone balance.

 

The smartDNA Advanced Pathways Test identifies gene variants that may affect your levels of key vitamins - helping you personalise your nutrition with precision.

 

What We Test

This panel focuses on genetic markers associated with reduced blood levels or impaired utilisation of:

  • Vitamin B2 (Riboflavin)

  • Vitamin B6 (Pyridoxine)

  • Vitamin B12 (Cobalamin)

  • Vitamin C (Ascorbic Acid)

  • Vitamin D

  • Vitamin E (Tocopherol)

Genes assessed include:

MTHFR, NBPF3, FUT2, GSTT1, GSTM1, SLC23A1, GC, DHCR7, CYP2R1, and INTERGENIC regions.

 

Why It Matters

Variants in these genes may result in:

  • Reduced absorption of vitamins from food or supplements

  • Increased breakdown or loss of vitamins under stress

  • Impaired transport to target tissues

  • Suboptimal levels, even with a balanced diet

 

METHYLATION - FOLATE AND COFACTORS

The Foundation of Detox, Hormone Balance, Mood & Energy 

 

Methylation is a key biochemical process that occurs billions of times per second in your body. It’s essential for detoxification, DNA repair, neurotransmitter production, hormone metabolism, and cardiovascular health.

 

This process depends on a steady supply of methyl groups — which are largely influenced by your genetics, diet (especially B vitamins), and lifestyle.

 

What We Test

 

The smartDNA Advanced Pathways Test analyses genes involved in the methylation cycle and folate metabolism, including:

 

MTHFR - helps convert folate into its active form (5-MTHF)

MTR / MTRR - support the conversion of homocysteine to methionine and the recycling of vitamin B12

CBS - regulates the breakdown of homocysteine into cysteine

TCN2 - affects vitamin B12 transport and availability

SLC19A1 - assists in folate transport into cells

 

Why It Matters

Variants in these genes may lead to:

  • Elevated homocysteine levels, increasing the risk of:

  • Peripheral vascular disease

  • Cerebral vascular disease (e.g. stroke)

  • Coronary artery disease

  • Thrombosis and clotting disorders

  • Impaired detoxification and neurotransmitter balance

  • Increased need for B2, B6, B9 (folate), and B12

  • Even subtle imbalances in this system can affect mood, energy, fertility, and cardiovascular health.

 

OXIDATIVE STRESS

Understanding Your Body’s Ability to Combat Cellular Damage

 

Oxidative stress is a major contributor to premature aging, chronic disease, and cellular damage. It occurs when the body’s antioxidant defences can’t keep up with the production of free radicals - unstable molecules generated by stress, toxins, poor diet, inflammation, and even normal metabolic processes.

 

Your genes play a crucial role in determining how well your body can neutralise these free radicals.

 

What We Test

 

The smartDNA Advanced Pathways Test assesses your antioxidant defence capacity by analysing key genes involved in detoxifying free radicals:

 

SOD2 (Superoxide Dismutase 2) – neutralises superoxide radicals in the mitochondria

GPX1 (Glutathione Peroxidase 1) – reduces hydrogen peroxide and supports glutathione activity

CAT (Catalase) – breaks down hydrogen peroxide into harmless water and oxygen

 

Why It Matters

Variants in these genes can reduce antioxidant enzyme activity, making you more susceptible to:

  • Oxidative damage to cells and tissues

  •  Accelerated aging and mitochondrial dysfunction

  • Inflammation and immune imbalances

  • Higher risk of chronic conditions such as cardiovascular disease, neurodegeneration, or metabolic disorders

 

DETOXIFICATION - PHASE I & PHASE II PATHWAYS

How Your Body Clears Hormones, Toxins, Metals & Medications

 

Your liver’s detoxification system works in two key phases to help break down and eliminate harmful substances — from hormones and medications to environmental toxins and heavy metals.

 

This process is highly influenced by your genetics, and understanding your detox capacity can provide valuable insight into fatigue, hormonal imbalance, skin issues, and chemical sensitivity.

 

What We Test

The smartDNA Advanced Pathways Test analyses key genes involved in both Phase I and Phase II detoxification:

Phase I Detoxification (Activation):

This phase transforms toxins into reactive intermediates — sometimes even more harmful than the original substance.

 

Genes tested:

CYP1A1 - metabolises estrogens, toxins, and carcinogens

CYP1B1 - associated with estrogen metabolism and cancer risk

COMT (Catechol-O-Methyltransferase) – breaks down estrogen metabolites, catecholamines, and neurotransmitters

 

These enzymes play a role in how your body processes caffeine, medications, alcohol, environmental toxins, and xenoestrogens (synthetic estrogens from plastics, chemicals, etc.).

 

Phase II Detoxification (Neutralisation & Elimination):

 

This phase neutralises and binds reactive Phase I metabolites, turning them into water-soluble compounds that can be excreted safely via urine or bile.

 

Genes tested:

 

GSTT1, GSTM1, GSTP1 (Glutathione S-transferases) - vital for glutathione activity and clearance of heavy metals, toxins, and oxidative by-products

 

Why It Matters

  • Overactive Phase I + Underactive Phase II = buildup of toxic intermediates

  • Increased sensitivity to medications, alcohol, or chemicals

  • Poor clearance of estrogens and xenoestrogens (linked to PMS, fibroids, estrogen dominance)

  •  Higher susceptibility to oxidative stress and inflammation

  • Impaired detox = fatigue, brain fog, hormonal imbalance, and skin issues

 

 

 What’s Included:

  •   Saliva-based DNA test kit (shipped directly to you)

  • Analysis of 300+ key genetic SNPs

  • Practitioner-only interpretation (with Olga)

  • Personalised treatment strategy (supplements, nutrition, lifestyle)

  • Note: Afterpay available through the testing lab for DNA testing

 How It Works:

1. Book a DNA Results & Interpretation Session on this website (5-6 weeks from today)

2. Within 24–48 hours, you’ll receive a link to purchase the DNA test

Cost: $473 AUD (includes GST) plus shipment (Afterpay available)

3. The lab will ship your saliva test kit to your address

4. You collect your sample (easy cheek swab) at home and return it to the lab

5. Allow 5-6 weeks for lab analysis and report generation

6. Once results are in, we’ll meet for your booked DNA interpretation session. Please note results are not released before the interpretation session. If the results of the testing won't arrive before the session or arrive without sufficient time for Olga to prepare for your session, you will be kindly contacted to move the appointment to the alternative suitable time.

 

 Costs:

SmartDNA Advanced Pathway Test (ordered via lab): $473 AUD plus shipment

(paid directly to SmartDNA/MTHFR Products – Afterpay available)

 

DNA Results Interpretation Session with Olga: $330 AUD (90 minutes)

 

Ready to personalise your healing path?

 

Tap below to book your DNA Interpretation Session. 

 

Have questions before booking?

Email: hello@thebodymindheart.com

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